Normal Signalling Nerves communicate with muscle fibers at a special synapse, the neuromuscular junction (NMJ). Here, the ends of the axon (synaptic end-bulbs) come very close to the membrane (sarcolemma) of the muscle fiber. The synaptic end-bulbs contain sacs (synaptic vesicles) filled with neurotransmitter. The neurotransmitter at the NMJ of skeletal muscles is always acetylcholine (Ach).
Pathophysiology of the Neuromuscular Junction
Pathophysiology of the Neuromuscular Junction
Pathophysiology of the Neuromuscular Junction
Normal Signalling Nerves communicate with muscle fibers at a special synapse, the neuromuscular junction (NMJ). Here, the ends of the axon (synaptic end-bulbs) come very close to the membrane (sarcolemma) of the muscle fiber. The synaptic end-bulbs contain sacs (synaptic vesicles) filled with neurotransmitter. The neurotransmitter at the NMJ of skeletal muscles is always acetylcholine (Ach).